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(10R)-1,8-Dihydroxy-3-(hydroxymethyl)-10-[(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one

aloin

CAS: 1415-73-2;5133-19-7

Molecular Formula: C21H22O9

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  5. (10R)-1,8-Dihydroxy-3-(hydroxymethyl)-10-[(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one

(10R)-1,8-Dihydroxy-3-(hydroxymethyl)-10-[(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one - Names and Identifiers

Name aloin
Synonyms aloin
Aloin
Barbaloin
barbaloin from aloe barbadensis*miller leaves
10-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone
10-beta-D-Glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone
1,8-Dihydroxy-10-(beta-D-glucopyranosyl)-3-(hydroxymethyl)-9(10H)-anthracenone
1,5-anhydro-1-[4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl]hexitol
4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl beta-D-glucopyranoside
(1S)-1,5-anhydro-1-[(9R)-4,5-dihydroxy-2-(hydroxymethyl)-10-oxo-9,10-dihydroanthracen-9-yl]-D-glucitol
(10R)-1,8-dihydroxy-3-(hydroxymethyl)-10-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]-10H-anthracen-9-one
(10R)-1,8-dihydroxy-3-methylol-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]-10H-anthracen-9-one
(10R)-1,8-Dihydroxy-3-(hydroxymethyl)-10-[(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one
(10R)-1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one
1,8-dihydroxy-3-(hydroxymethyl)-10-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]-10H-anthracen-9-one
10-Glucopyranosyl-1,8-dihydro-3-(hydroxymethyl)-9-anthracenone, (10S)-beta-D-Glucopyranoside-aloe, Aloin A, Aloe-Emodin, Moquizone
CAS 1415-73-2
5133-19-7
EINECS 610-650-2
InChI InChI=1/C21H22O9/c22-6-8-4-10-14(21-20(29)19(28)17(26)13(7-23)30-21)9-2-1-3-11(24)15(9)18(27)16(10)12(25)5-8/h1-5,13-14,17,19-26,28-29H,6-7H2/t13-,14?,17-,19+,20-,21+/m1/s1

(10R)-1,8-Dihydroxy-3-(hydroxymethyl)-10-[(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one - Physico-chemical Properties

Molecular FormulaC21H22O9
Molar Mass418.39
Density1.648g/cm3
Melting Point148-149°; monohydrate, mp 70-80°
Boling Point752.602°C at 760 mmHg
Specific Rotation(α)+21°(water)
Flash Point267.997°C
Solubility Soluble in pyridine, soluble in glacial acetic acid, formic acid, acetone, methyl acetate, and ethanol.
Vapor Presure0mmHg at 25°C
AppearanceYellow or yellowish crystalline powder
Storage Condition2-8℃
Refractive Index1.741
MDLMFCD00151160

(10R)-1,8-Dihydroxy-3-(hydroxymethyl)-10-[(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk CodesR36/37/38 - Irritating to eyes, respiratory system and skin.
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.

(10R)-1,8-Dihydroxy-3-(hydroxymethyl)-10-[(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one - Reference

Reference
Show more
1. Liu Weibin, Ge Mingjian, Ye Xiaoye, et al. Study on the Effect of Aloin Combined with Cisplatin on Non-small Cell Lung Cancer Cells [J]. Chinese Journal of Clinical Pharmacology, 2020, v.36;No.304(02):56-59.
2. Ji Huijie, Yang Yanjun, Xue Junli, et al. Study on Ultrasonic Extraction of Aloin from Aloe [J]. Heilongjiang Agricultural Sciences, 2015(2):94-98.
3. Qian Wenhui, Liu Wenya, Gong Guangming, et al. Preparation of mistletoe-Lu whitening sunscreen gel and investigation of its in vitro transdermal behavior [J]. Chinese Pharmacist, 2020, v.23(06):97-101.
4. Jiang, Kangfeng, et al. "Barbaloin protects against lipopolysaccharide (LPS)-induced acute lung injury by inhibiting the ROS-mediated PI3K/AKT/NF-κB pathway." International immunopharmacology 64 (2018): 140-150.https://doi.org/10.1016/j. insimp. 2018.08.023
5. [IF=3.361] Kangfeng Jiang et al."Barbaloin protects against lipopolysaccharide (LPS)-induced acute lung injury by inhibiting the ROS-mediated PI3K/AKT/NF-κB pathway."Int Immunopharmacol. 2018 Nov;64:140
6. [IF=4.36] Gaofeng Shi et al."Aloe vera mitigates dextran sulfate sodium-induced rat ulcerative colitis by potentiating colon mucus barrier."J Ethnopharmacol. 2021 Oct;279:114108
7. [IF=2.391] Zhang Xiao et al."Graphene oxide exhibited positive effects on the growth of Aloe vera L."Physiol Mol Biol Pla. 2021 Apr;27(4):815-824
8. [IF=4.451] Furong Wang et al.Network pharmacology combined with metabolomics to investigate the anti-hyperlipidemia mechanism of a novel combination.J Funct Foods. 2021 Dec;87:104848
9. [IF=2.552] Wang Sha et al."A newly isolated human intestinal strain deglycosylating flavonoid C- glycosides."ARCHIVES OF MICROBIOLOGY. 2022 Jun;204(6):1-8

(10R)-1,8-Dihydroxy-3-(hydroxymethyl)-10-[(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one - Reference Information

introduction aloin is a natural organic compound, the English name is Aloin or Barbaloin, also known as aloin, aloe emodin, aloin, and aloin. it crystallizes in ethanol as yellow needle-like crystals. Easily soluble in water, pyridine, soluble in glacial acetic acid, formic acid, acetone, methyl acetate and ethanol. It is a concentrated dried sap of the leaves of the monocotyledonous plants, the AloebarbadensisMiller of Aloe vera, the Cape of Good Hope AloeferoxMiller, or other related plants of the same genus (such as Aloe vera).
efficacy and action aloin, a kind of anthraquinone compound, that is, the yellow liquid between aloe leaf surface and aloe gel, has the effect of deworming and disinfection. In medicine, aloin has a venting effect and is used to treat constipation. Aloin has the physiological effects of purgative effect, depigmentation, tyrosinase inhibition, free radical scavenging effect and antibacterial activity.
application aloin, chemical name 10-glucopyranosyl -1,8-dihydroxy -3-(hydroxymethyl)-9(10H)-anthrone. The active ingredient is a mixture of aloin, which is a dicotyledonous aloe extract. It has bactericidal and detoxifying effects on acne and acne.
Last Update：2024-04-09 21:48:26
(10R)-1,8-Dihydroxy-3-(hydroxymethyl)-10-[(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one
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Shanghai Yuanye Bio-Technology Co., Ltd.
Featured ProductsMultiple SpecificationsSpot supply
Product Name: Aloin Visit Supplier Webpage Request for quotation
CAS: 1415-73-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: aloin Request for quotation
CAS: 1415-73-2
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: aloin Request for quotation
CAS: 1415-73-2
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: aloin Request for quotation
CAS: 1415-73-2
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Changsha Staherb Natural Ingredients Co., Ltd.,
Spot supply
Product Name: Aloin Visit Supplier Webpage Request for quotation
CAS: 5133-19-7
Tel: +86-(0)731-84213302
Email: sales@staherb.cn
Mobile: +86 13875855783
QQ: 484702402 Click to send a QQ message
WhatsApp: +86 18374838656
Linkedin: +86 18374838656
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(10R)-1,8-Dihydroxy-3-(hydroxymethyl)-10-[(2S,3S,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-10H-anthracen-9-one
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